Abstract
This study was conducted to test the efficacy and toxicity of cetuximab and irinotecan as a biweekly regimen in treatment of elderly patients with metastatic colorectal cancer (mCRC). Forty-nine elderly patients (≥65years) with mCRC who progressed after at least one previous line of treatment were enrolled into this study from May 2008 to January 2011. All recruited patients received cetuximab 500mg/m(2) and irinotecan 180mg/m(2) every 2weeks. Thirty-seven patients (76%) were men, and 76% of patients had colonic cancer in origin. Median age was 69years. Median overall survival time was 7months, and median progression-free survival was 4months. Grade 3-4 skin rash occurred in 20% of patients, grade 3-4 diarrhea in 18% of patients, and neutropenia in 28% of patients. Cetuximab combined with irinotecan when administered biweekly is safe and effective for treatment of pretreated elderly patients with mCRC.
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