Abstract
Objectives: The main objective of the study was to explore the in-vivo anti-diarrheal properties of Methanol, Ethanol, Hot and Coldwater fractions of Cassia abbreviata (Fabaceae) stem bark in mice model in order to validate its traditional use.
 Study Design: This study was an experimental based study, where we used 30 Swiss albino mice and these were divided into five groups of six mice.
 Methods: The test groups (group three, four and five) received various doses of the crude extracts (100, 200 and 400 mg/kg) respectively, whereas the positive control (group two) received Loperamide (5mg/kg) as standard reference drug and negative control (group one) received distilled water (10ml/kg). The antidiarrheal activity of the four extracts from stem bark of Cassia abbreviata were evaluated in a castor oil-induced diarrhea model in mice and compared with Loperamide. Whereas the effect of methanol extract on gastrointestinal motility was also determined by the oral administration of charcoal meal. Data was analyzed using STATA version 13, presented as means and standard deviation, ANOVA, Bonferroni post hoc and Pearson tests were done.
 Results: The severity of diarrhea was reduced significantly (p<0.001) by the four extracts (400mg/kg doses) where Methanol, Ethanol, Hot and Coldwater extracts had 64.5%, 62.4%, 60.9% and 59.7% respectively, whereas the standard drug Loperamide had 67.7% diarrhea inhibition. This was evidenced by reduction in frequency of diarrheal episodes and stool outputs when compared to the control group. The intestinal peristalsis was significantly (p<0.001) reduced by methanol extract (53.3%) at 400mg/kg when compared to Loperamide (65.5%). 
 Conclusion: It was concluded that all the four extracts from the stem bark of Cassia abbreviata scientifically displayed anti-diarrheal properties, which require further scientific studies leading to identification of the actual compounds.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
