Abstract
Learng Pid Samud (LPS) recipe is a traditional remedy in Thai folk medicine to ease the common diarrhea. The anti-diarrheal potential of LPS recipe was herein examined in vitro using a guinea-pig ileum model. The LPS exerted an inhibitory effect on acetylcholine-induced smooth muscle contraction in the guinea pig ileum. Significantly, not only did the LPS reduce the total amount of feces in the induced diarrhea rats, but also the intestinal transit in the charcoal meal test. A single oral administration with the recipe at 5,000 mg/kg did not cause acute toxicity and the daily oral administration (1,000, 2,000 and 4,000 mg/kg) for 90 days in rats did not produce any toxic signs and symptoms. In conclusion, the Learng Pid Samud recipe remedy is evidently safe and effective for the anti-diarrheal treatment which supports its therapeutic uses in the alternative medicine.
Highlights
Diarrhea is one of the most common illnesses in all age groups
Learng Pid Samud is used as anti-diarrheal remedy in Thai folk medicine
Diarrhea is a condition in which the frequency of bowel movements is increased or the form of stool decreased
Summary
Diarrhea is one of the most common illnesses in all age groups. It is an uncomfortable condition that can have many causes, and vital gastroenteritis (stomach flu) is one of the most common causes of diarrhea. Learng Pid Samud (LPS) recipe is a household remedy in the National List of Essential Medicines of Thailand, for the treatment of non-infectious diarrhea. All plants in LPS recipe except resin from plants in Dipterocarpaceae family and resin of L. chinensis show gastrointestinal effects and anti-diarrheal activity (Rajkumar et al, 2011; Chengaiah et al, 2010; Meena et al, 2010; Rabbani et al, 2010; Sawangjaroen and Sawangjaroen, 2005; Taufiq-Ur-Rahman et al, 2005; Rabbani et al, 2004; Sharma et al, 2001; Das et al, 1999; Joy et al, 1998). The scientific data to support the reputed anti-diarrheal activity and toxicity of the LPS recipe have not yet been substantiated. The objective of this study was to evaluate the anti-diarrheal activity and safety of this recipe
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