Abstract
Ethnopharmacological relevanceThrough one-to-one interaction with the traditional healers, the present study has identified 15 medicinal plant species traditionally used as remedies to control diabetes. Materials and methodsThe methanolic extracts were screened for their α-glucosidase inhibitory activity. Hypoglycemic activity was assessed following glucose, sucrose and starch tolerance test on normal and STZ induced diabetic rats. ResultsFicus cunia extract had the highest α-glucosidase inhibitory potency with IC50 1.39±0.74µgmL−1 followed by Schima wallichi (IC50 1.43±0.20µgmL−1) and Wendlandia glabrata (IC50 1.67±0.33µgmL−1). In STZ induced diabetic rat model, F. cunia and W glabrata extracts reduced blood glucose concentration to near normal up to 14 days when administered 48h after STZ. ConclusionThe present study supports the traditional use of some of these medicinal plants in anti-diabetic remedies. The present study contributes to evidence for use of traditional medicine.
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