Abstract
Objective: The rats were randomly divided into 5 groups and each group consisted of 6 rats and the duration of treatment was 45 days. Body weight, fasting plasma glucose levels, SGOT, SGPT and ALP levels were measured.
 Methods: Albino Wistar male rats; 10- weeks old with a bodyweight ranged between 180-250 g were used. Anti-diabetic effect of plant Costus spicatus. In rhizome extract of ethanol extract.
 Result: The present study clearly indicates in the form of administration of C. spicatus rhizome extract towards glucose fed mice normalizes blood glucose level. Recent studies have revealed induced diabetic rats caused anti-diabetic effects. Histopathological studies of Pancreasin diabetic and treated groups are determined to show the protective action of the ECS. The administration of STZ resulted in a significant increase in plasma glucose level, SGOT, SGPT and ALP along with a reduction in body weight.
 Conclusion: All these effects were observed on 45th day. ECS and Glibenclamide of STZ induced diabetic animals restored the normal plasma glucose levels and SGOT, SGPT and ALP levels without damaging the pancreas.
 Keywords:Anti-hypolipidemic, diabetes mellitus, peripheral insulin resistance, pancreatic, STZ.
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