Anti-diabetic Activity of Buchanania lanceolata Wight Extracts in Streptozocin persuade Diabetic Animal Model

Abstract

Diabetes mellitus is a well-established metabolic syndrome that originates from a complete or virtual requirement of insulin and low insulin action, which leads to hyperglycemia and malformation in the regulation of lipids, proteins, and carbohydrates. Micro and macrovascular difficulties are mainly developed in diabetic patients when compared with normal individuals. The plant variety selected for this study was Buchanania lanceolata Wight (B. lanceolata), which comes under the family of Anacardiaceae, which was originated in India and Myanmar. In the current research, an aqueous extract of B. lanceolata was isolated from the plant barks. Glucose uptake was carried out by using L6 myoblast cell lines, and the results showed an improved glucose uptake in vitro by the aqueous extract of bark of B. lanceolata. Moreover, it was also studied for acute dose oral toxicity and anti-diabetic studies in Wistar albino rats. The aqueous extract did not demonstrate any toxic conditions or mortality at single dose feeding of 2000 mg/kg/p.o and was examined for 15 days. It was also found out the variations in glucose level, hematology parameters, lipid level, and biochemical factors of both control and treated animals. Currently, the natural drug gained attention among researchers because of the problems developed by the allopathic remedial representative. The examination of anti-diabetic agents of an herbal source that are used in folk medicine is thus of huge significance. Management of diabetes with artificial medicines is an expensive and high probability for side effects. As a result, it is necessary to develop plant-based medicines for diabetes. B. lanceolata is a promising herbal drug for diabetic treatment not only in Ayurveda but also in other folk medicine.