Abstract
A new marine ecdysteroid with an α-hydroxy group attaching at C-4 instead of attaching at C-2 and C-3, named palythone A (1), together with eight known compounds (2–9) were obtained from the ethanolic extract of the Formosan zoanthid Palythoa mutuki. The structures of those compounds were mainly determined by NMR spectroscopic data analyses. The absolute configuration of 1 was further confirmed by comparing experimental and calculated circular dichroism (CD) spectra. Anti-dengue virus 2 activity and cytotoxicity of five isolated compounds were evaluated using virus infectious system and [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assays, respectively. As a result, peridinin (9) exhibited strong antiviral activity (IC50 = 4.50 ± 0.46 μg/mL), which is better than that of the positive control, 2′CMC. It is the first carotene-like substance possessing anti-dengue virus activity. In addition, the structural diversity and bioactivity of the isolates were compared by using a ChemGPS–NP computational analysis. The ChemGPS–NP data suggested natural products with anti-dengue virus activity locate closely in the chemical space.
Highlights
IntroductionZoanthid the genus genus PalythoaPalythoa (family kind of of benthos benthos commonly commonly found found in in Zoanthid of of the Sphenopidae) is is aa kind shallow waters.More than species of this genus were identified in subtropical and tropical areas shallow waters
The animal materials of P. mutuki were collected in the northeast coast of Taiwan
The results indicated that it can inhibit all sero-types of DENV
Summary
Palythoa (family (family Sphenopidae) kind of of benthos benthos commonly commonly found found in in Zoanthid of of the Sphenopidae) is is aa kind shallow waters. More than species of this genus were identified in subtropical and tropical areas shallow waters. More than 90 species of this genus were identified in subtropical and tropical areas all over the the world. This characterized by by absorbing sands or or small small sediments sediments into all over. This marine marine creature creature is is characterized absorbing sands into polyp to reinforce their structure. Apart from the well-known poisonous compound, polyp to reinforce their structure. Apart from the well-known poisonous compound, palytoxin palytoxin [1],
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