Abstract
Anti-dengue serotype-2 activity effect of Sambucus nigra leaves-and flowers-derived compounds
Highlights
Dengue is caused by any of four dengue virus serotypes (DENV1, -2, -3, or -4)
S. nigra methanolic extracts from both, leaves and flowers, exhibited anti-dengue virus serotype-2 (DENV-2) activity at 400 μg/mL, when DENV-2 was pre-incubated with the extracts before being added to cell cultures
S. nigra was selected as a possible source of anti-DENV compounds based on its ethnopharmacological characteristics and known antiviral activity [23,24,25]
Summary
Dengue is caused by any of four dengue virus serotypes (DENV1, -2, -3, or -4). Every year an estimated of 390 million people are infected worldwide [1]. Despite considerable research aimed at the development of effective anti-dengue therapeutic drugs or vaccines, up to date a worldwide successful vaccination program is still missing. An interesting alternative approach for dengue treatment, is the use of medicinal plant-derived compounds, since plant extracts have been therapeutically used since ancient times, and, in many instances, have proven to be effective [69]. Some medicinal plants have shown strong antiviral activity, and inhibition of the replicative cycle, both for DNA and RNA viruses [10]. Even the World Health Organization (WHO) has advocated that in DENV endemic areas, traditional medicine should be considered with the purpose of identifying safe and effective antiviral therapeutics. Protective vaccines and effective anti-dengue treatments are still missing. Widely distributed in Mexico, has long been used in traditional medicine, including for some viral infections
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