Abstract
© symptoms.5 It is speculated that the therapeutic benefit of IFN-α is related to its combined antilymphoproliferative and antiviral actions.5 Given the availability of a specific therapy, it is important that HCV-associated type II cryoglobulinemia be recognized and diagnosed as early as possible. It should be part of the differential diagnosis in patients with an unexplained IgM M-protein, signs/symptoms of cryoglobulinemia, a positive cryoglobulin assay, and/or an unexplained positive rheumatoid factor assay.
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