Abstract
Results Records of 52 patients (54% males, 46% females) were reviewed. The mean (SD) age and follow-up period were 10.69 (3.81) and 2.3 (1.7) years, respectively. The majority of the children (83%) were Black. The subtypes of JIA were as follows: systemic 21%, polyarticular 50%, oligoarticular 19%, enthesitis-related arthritis 2%, psoriatic 2% and other 6%. Anti-CCP antibodies were present in the sera of 8 of 28 patients tested (29%). They were detected exclusively in patients with the polyarticular subtype of JIA. IgM RF was positive in 14 (29.17%) of the total cohort, but not exclusively in patients with the polyarticular subtype of JIA. The overall concordance between the 2 tests was fair (Kappa statistic = 0.39).
Highlights
Anti-cyclic citrullinated peptide antibodies are a highly specific serological marker for adult-onset rheumatoid arthritis, present early in the course of the disease, and are a marker of erosive disease
15th Paediatric Rheumatology European Society (PreS) Congress Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
To assess the prevalence and clinical significance of antiCCP antibodies in a cohort of children with juvenile idiopathic arthritis (JIA)
Summary
Anti-cyclic citrullinated peptide (anti-CCP) antibodies are a highly specific serological marker for adult-onset rheumatoid arthritis, present early in the course of the disease, and are a marker of erosive disease. Anti-cyclic citrullinated peptide: its prevalence and clinical significance in a South African cohort with juvenile idiopathic arthritis BJ Mistry*1,2, G Faller1 and M Tikly1 Address: 1Chris Hani Baragwanth Hospital, Johanessburg, Gauteng province, South Africa and 2University of Witwatersrand, Johanessburg, Gauteng province, South Africa
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