Abstract
The presence of anti-CV2 autoantibodies correlates with the existence of a paraneoplastic neurological syndrome. Their detection should lead to a search for an occult cancer. Although less frequent than anti-Hu autoantibodies, anti-CV2 autoantibodies seem to occur in patients with similar clinical pictures and tumors to those with anti-Hu anti-bodies. Furthermore, the detection of anti-CV2 autoantibodies is a good tool for predicting the presence of an occult cancer (frequently a SCLC) in anti-Hu-negative patients and with a clinical presentation suggestive of a paraneoplastic neurological syndrome.
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