Abstract
Anti-Contractile Mechanism of Resveratrol in Non-Vascular Smooth Muscle Under α1Adrenoceptor Stimulation involves IP3 Receptor, Protein Kinase-C and NADPH Oxidase
Highlights
Reactive oxygen species (ROS) are products of most metabolic reactions [1]
Phenylephrine was dissolved in distilled water; resveratrol was dissolved in 70% v/v ethanol, and 2-aminoethoxydiphenyl borate (2-APB) was dissolved in methanol with further dilution in distilled water before use
The results suggest that ROS sensitive to RESV are possibly derived from activation of α1-adrenoceptors with PE
Summary
Reactive oxygen species (ROS) are products of most metabolic reactions [1] When their production exceeds the physiological antioxidant protection that cells can withstand, harmful and damaging effects occur, such as lipid peroxidation and DNA oxidation. This imbalance is responsible for several diseases such as cancer, cardiovascular diseases like atherosclerosis and hypertension, and several complications of Diabetes Mellitus [2]. Ca2+ mobilization is related to diseases and worrisome lesions, and to muscle contraction, which will be covered in this article. Cytosolic calcium concentration ([Ca2+]c) increases triggering of the Ca2+-calmodulin complexation, which is essential for the muscle contraction due to activation via phosphorylation of myosin light chain (MLC) [8].
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