Anti-carcinoma and anti -microbial behavioral studies for octahedral synthesized Schiff base metal complexes

Abstract

2,2′-((1Z-1′Z) (1,3-diphenylpropane-1,3-diylidene) bis (azanylylidene)) dibenzoic acid (H2L) Schiff base ligand, derived from condensation reaction in a molar ratio 2:1 between anthranilic acid and dibenzoyl methane, respectively. Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes were obtained from 1:1 (ligand: metal salt) reaction. Elemental analyses, IR, 1H NMR, UV–Vis, ESR, mass spectra, conductivity, and magnetic susceptibility measurements as well as thermal (TG/DTG) analyses have been used to conclude the molecular structure of the prepared complexes. From the analytical and spectroscopic tools, the stoichiometry of the complexes was found to be of ML type with octahedral geometry. The conductivity values supported the electrolytic nature of Cr(III) and Fe(III) complexes and non- electrolytic nature of the remaining complexes. From IR studies, the involvement of two azomethine nitrogen atoms and two carboxylate oxygen has been proved as tetradendate binding sites of the ligand. Screening Schiff base and its complexes for their antimicrobial activity against Streptococcus pneumoniae and Bacillus subtilis as G + bacteria; Pseudomonas aeruginosa and Escherichia coli as G− bacteria) and fungi (Aspergillus fumigatus; Syncephalastrum racemosum; Geotricum candidum and Candida albicans) has been conducted by disk diffusion method. The Comparison between the antimicrobial activity of the metal complexes and the free ligand showed the advancement of the metal complexes. Unfortunately, no promising anti-tumor activity has been detected for the ligand and its metal complexes as they were evaluated against human cancer (MCF-7 cells viability).