Abstract
Anti-Carbamylated antibodies as a marker of activity and disability in Rheumatoid Arthritis
Highlights
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, characterized by synovitis, bone and cartilage damage, systemic inflammation and generation of autoantibodies[1]
ACPA have significantly improved its diagnosis but it is unquestionable that there is a demand for a novel antibodies to add a more diagnostic value as well as to stratify patients according to different disease phenotype[24, 25]
This study was to evaluate the anti-carp in patients with RA and its relation to disease activity as well as functional assessment
Summary
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, characterized by synovitis, bone and cartilage damage, systemic inflammation and generation of autoantibodies[1]. In order to be adherent to these recommendations, regular assessment of disease activity is recommended in routine care[3]. Different clinical activity measures were recommended; the Clinical Disease Activity Index (CDAI), Disease Activity Score in 28 joints (DAS28), Patient Activity Scale (PAS), Patient Activity Scale II (PAS-II), Routine Assessment of Patient Index Data (RAPID3), and Simplified Disease Activity Index (SDAI)[4]. There are some limitations regarding the use of these scores like musculoskeletal ultrasound or magnetic resonance imaging[3]. These scores which include patient reported measures may show a higher activity measures in subpopulation of RA with comorbid fibromyalgia[5]. Providing recommendations for disease activity assessment in such specific situations are left to the treating physician[3]. Recent autoantibodies has been described which react against Carbamylated proteins (anti-Car-P) carbamylation as citrullination are post-translational modifications which end in the production of homocitrulline and citrulline respectively
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