Abstract
Serial determinations of anti-Candida agglutinating and precipitating antibodies were carried out prospectively over a period of eighteen months on 154 patients with acute leukemia. During this study visceral candidiasis developed in fourteen patients. A significant rise in agglutinating antibody titer was noted in seven of these patients, and in three additional patients blood cultures grew Candida species. Thus an antemortem diagnosis of candidiasis was made in ten of fourteen patients with this infection. A “false” rise in antibody titer occurred in patients with other disseminated fungal infections, in patients with fever of unknown origin which resolved spontaneously with regression in the patient's leukemia and in one patient with pulmonary tuberculosis. We recommend serial determinations of anti-Candida agglutinating antibody titers in groups of patients known to have increased susceptibility to fungal infections, as this is the most reliable means for diagnosing visceral candidiasis.
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