Abstract
Summary Objective To screen anti- Candida albicans activity of the essential oils of 16 Iranian medicinal plants. Materials and methods Anti- C. albicans effect of plant oils, amphotericin B, nystatin and ketoconazole were determined by disc diffusion and broth macrodilution methods. Results Fourteen (87%) out of the 16 plants were found to be active. These oils confirmed the existence of a significant activity against C. albicans tested with minimal inhibitory concentration (MIC) values ranging from 150 to 2300 μg/ml using broth macrodilution method and the growth inhibition zone ranging from 16 to 55 mm using disc diffusion method. The essential oils of Zataria multiflora, Thymus kotschyanus, Cuminum cyminum and Plargonium graveolens showed significant activity against C. albicans ( P Conclusion The oils that showed strong anti- Candida activity are worth of further investigations in order to identify the active compounds and their clinical applications for the treatment of candidiasis.
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