Abstract
In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized and characterized by marine endophytic actinomycete Streptomyces coeruleorubidus (S. coeruleorubidus). In result, the 380 nm spectrum of the synthesized peak was confirmed as ZnO NPs. Uniform sized nanoparticles that particle size was distributed in the range from 6 nm to 195 nm. The exact ZnO NPs morphology was clearly shown by transmission electron microscope analysis. In addition, the single crystalline or poly crystalline or amorphous nature of the ZnO NPs was clearly indicated by the result of SAED. The XRD diffraction and EDX values were more high and confirmed as ZnO NPs. Further, the antibiofilm properties of the biosynthesized ZnO NPs was exhibited 32 mm zone of inhibition against biofilm producing K. pneumoniae at 1000 µg/mL concentration. The 98% of biofilm eradication in K. pneumoniae was observed after treatment with ZnO NPs at 24 h. Furthermore, the survival fitness of the biofilm cells were degraded very high rate at 1000 µg/mL concentration of ZnO NPs. Altogether, the present result was proved that the biosynthesized ZnO NPs was very effective against biofilm forming K. pneumoniae at very low concentration, and it is an alternative drug candidate molecule in future drug discovery process.
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