Abstract
A series of quinoxaline 1,4-di-N-oxide derivatives, which have been proven to be active cytotoxic agents under hypoxic conditionswere synthesized. Ethyl-3-hydroxyquinoxaline-2-carboxylate (1) on reaction with hydrazine hydrate in ethanol yielded 3-hydroxyquinoxaline-2-carbohydrazide(2). This product on condensation with different aromatic aldehydes yielded N-4-bromobenzylidine)-3-hydroxyquinoxaline-2-carbohydrazide(3) which upon reaction with mCPBA in THF resulted in the abovementionedproducts. These derivatives were evaluated for theiranti-bacterial activity using four different strains. A few compounds among them were also evaluated for their anti-tumour activity towards breast cancer (MCF7) and cervical cancer (HeLa) cell lines. Compound 4a showed moderate activity towards breast cancer cell lines (MCF7) and 4b towards cervical cancer cell lines (HeLa). All the compounds were characterized by IR, 1H NMR and Mass spectroscopy.
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