Abstract
We studied the reactivity of monoclonal antibodies L26 and MB2 in 24 thymectomies for myasthaenia gravis(MG) and 14 thymectomies for thymoma without MG. A previous study has indicated that the presence of L26+ and MB2+ aggregates may be a sensitive means of detecting thymic lymphoid hyper-plasia(TLH). Sections were selected at random from cases without thymoma. Sections from thymomas were selected to include adjacent thymus where possible. Morphology and pattern of L26/MB2 staining was noted; specifically for aggregates of positive cells indicative of TLH and this was compared with the HE TLH is present in at least 83.3% of MG thymuses, at least 81.8% of MG thymomas, at least 50% of non-MG thymomas, and at least 68.0% of thymomas overall. The role of TLH and thymoma in MG and the role of TLH in thymoma should be re-assessed.
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