Abstract
The present attempt was aimed to evaluate the anti-asthmatic and anti-allergic activity of the aqueous extract of Lagenaria siceraria leaf (LSA) using various animal models like histamine and acetylcholine induced bronchoconstriction in Guinea pigs, compound 48/80 induced mast cell degranulation in rats and paw edema in mice. LSA exhibited significant and dose dependent bronchodilatory activity at the doses of 150 and 300 mg/kg intraperitonially (i.p.). LSA at the concentrations of 10, 20 and 30 I¼g/ml significantly inhibited compound 48/80 induced mast cell degranulation. The anti inflammatory activity was observed at the doses of 50, 75 and 100 mg/kg (i.p.) against compound 48/80 induced paw edema in rats. These results prove the traditional claim of the drug in treatment of asthmatic disorders.
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