Abstract
Aim of the study: To investigate Anti-Arthritic activity of Methanolic Extract of Abies webbiana Lindl. (MEAW) leaves in complete Freund’s adjuvant- induced arthritis in albino rats. Methods: RA was induced in all study groups 2-6 except group 1 by sub-plantar injection of 0.1mlkg-1 of CFA agent in left hind paw of albino rats. Group 1 demonstrates Normal control. Group 2 serves as Arthritic control and Group 3 illustrates Standard control (Methotrexate 0.5mgkg-1). Group 4-6 serves as Test control receiving differing doses of MEAW of 100, 200 & 400mgkg-1. Treatment commences after 8th day of CFA induction in a manner of single dose (p.o.) a day for 20 successive days. Meanwhile, invitro parameters of body weight and paw volume were measured & after day 28th hematological, biochemical, anti-oxidant & histopathological parameters were characterized. Results: MEAW demonstrated dose dependent anti-arthritic activity which was evident with decrease in paw volume & increase in body weight when compared to arthritic control group. MEAW (400 & 200mg/kg) exhibited significant (p<0.001) anti-arthritic activity by surging levels of RBC, Hb & equalizing the levels of WBC, Platelets, ESR, CRP & RF.
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