Anti-arrhythmic effect of oxyfedrin

Abstract

Oxyfedrin, L-3-methoxy-(l-hydroxy-l-phenylisopropylamino)-propiophenone hydrochloride, displays in rats and dogs a pronounced anti-arrhythmic effect against spontaneous and drug-induced arrhythmias (ouabain, barium chloride, aconitine). Doses of 1 mg/kg, given intramuscularly (i.m.) or intravenously (i.v.) offered protection against chloroform-adrenaline-induced ventricular fibrillation. The mechanisms possibly involved in the anti-arrhythmic activity of oxyfedrine are discussed.