Anti‐apoptotic effect of Korean ginseng extract on aging‐induced ovary via inhibition of p63 signaling pathway in mouse

Abstract

BackgroundThe problem of women's subfertility has been steadily increasing worldwide, and many studies are under way to treat it. The ovary is a key element in the problem of subfertility, and it is very important to maintain integrity. Recently, the pregnancy age of women is increasing, and so the function of the ovary is deteriorated with aging. Korean ginseng has been widely used as a herb medicine and it is known to contain many beneficial biological properties. We investigated the effect of Korean ginseng extract (KGE) on ovary function of female.MethodsThe ovaries were harvested from 6‐month‐old female mice and cultured in the KGE‐treated media for 24 hours. After that, RNA was extracted from the control and KGE‐treated groups and microarray was performed. In addition, based on the microarray data, the gene expression was verified by qPCR.ResultsAging dramatically increased expression of apoptosis regulatory factors in ovary, but expression of these factors was significantly reduced in the KGE‐treated groups. Expression levels of apoptosis regulatory factors such as p63, NOXA, BCL2 and BAX were increased in the ovary with aging. KGEs reduced the expression level of these factors. Consequently, KGEs helps to maintain ovary function by suppressing apoptotic damage caused by aging.ConclusionsWe suggest that KGEs protect against aging‐induced ovary damage by inhibiting apoptosis signaling pathway.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.