Abstract
This study was conducted to determine the anti-angiogenic effects of different concentrations of mimosine, flavonoids, tannins, etc. from aqueous root extract (ARE) of Mimosa pudica L. (Fabaceae) on the chorioallantoic membrane (CAM) of developing duck embryo. The extraction method was done by air-drying, grounding and decoction. The AREs of M. pudica were prepared at different concentrations (10%, 20% and 30%). These were administered on the CAM of the 10-day old duck embryos. After 48 h upon administration of the extracts, the secondary branching points on the CAM are counted and compared with the control groups and with each of the experimental groups. The results reveal that AREs of M. pudica inhibited anti-angiogenesis. Results show that 10%, 20% and 30% concentrations have significantly yielded anti-angiogenic results. There is a significant difference between all the control groups and the experimental groups indicating that as the concentration increases, the branching point of the embryos decreases. This suggests the potential use of the M. pudica root extract for further studies on abnormal angiogenesis and evasion of apoptosis as hallmarks in cancer treatment.
Highlights
Angiogenesis is the process of developing new blood vessels and controlled by certain chemicals produced in the body [1]
The aqueous root extract of M. pudica L. extracted via decoction were administered to each of the test eggs on its 10th day of incubation period
The anti-angiogenic property was apparent for the duck embryos treated with various concentration if M. pudica aqueous extract with the embryos treated with highest dose showing the least developed blood vessels which is the 30% concentration
Summary
Angiogenesis is the process of developing new blood vessels and controlled by certain chemicals produced in the body [1]. It is critically important during the normal development of the embryo and fetus. Anti-angiogenic and proapoptotic therapies are effective strategies for cancer treatment. Medicinal plants such as Eugenia jambolana (Myrtaceae), Musa paradisiaca L. (Cucurbitaceae) have been investigated recently for their anti-cancer potential [4] This indicates wider latitudes for studying other medicinal plants such as the genus Mimosa (Fabaceae), this study
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