Abstract
We reviewed all fully published clinical trials assessing anti-angiogenic agents in sarcoma patients (last issue, January 13, 2020). Anti-angiogenic macromolecules (e.g., bevacizumab or ombrabulin) provide disappointing results. Many multikinase inhibitors have been assessed with non-randomized phase II trials with limited samples and without stratification according to histological subtypes, therefore interpretation of such trials is very challenging. On the contrary, pazopanib, regorafenib, and sorafenib have been assessed using double-blind placebo-controlled randomized phase II or phase III trials. Compared to placebo, sorafenib demonstrates activity in desmoid-type fibromatosis patients. Based on results of phase 3 trial, pazopanib had obtained approval for treatment of pretreated non-adipocytic soft tissue sarcoma. Regorafenib is currently assessed in several clinical settings and provides significant improvement of progression-free survival in pre-treated non-adipocytic soft tissue sarcoma and in advanced pretreated osteosarcoma. Multikinase inhibitors are a breakthrough in sarcoma management. Many trials are ongoing. Nevertheless, predictive factors are still missing.
Highlights
Sarcoma represents less than 2% of adult malignancies and about 15% to 20% of malignancies in children and adolescents/young adults
ORR, objective response rate according to response evaluation criteria in solid tumors (RECIST); progression-free survival rates (PFR), progression-free survival rate; PFS, progression-free survival; OS, overall survival; HR, hazard ratio; 95% CI, 95% confidence interval
Macromolecules acting as anti-antiangiogenic agents provide disappointing results in clinical trials
Summary
Sarcoma represents less than 2% of adult malignancies and about 15% to 20% of malignancies in children and adolescents/young adults. Sarcomas account for more than 80 different clinico-. Because of heterogeneity of sarcomas, recommended systemic treatments widely differed according to histological subtypes: kinase inhibitor targeting c-Kit and PDGFR-a in gastro-intestinal stromal tumors, hormonal therapy in some particular rare entities, molecular targeted therapies in some rare entities, and chemotherapy in most of clinical settings. In the past two decades, many clinical trials assessed the therapeutic role of checkpoint inhibitors in sarcoma patients, but results remain disappointing. There is a growing body of evidence that anti-angiogenic, and especially multikinase inhibitors constitute a breakthrough in management of sarcoma patients. The objective of the present study was to summarized the published data about activity of antiangiogenic agents in sarcoma patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
