Abstract
Background and aims Cancer has affected humans since the ancient times. One of the class of cancer treatment is targeted drugs which includes angiogenesis inhibitors or anti-angiogenics. The formation of new blood vessels is called angiogenesis. These class of drugs will affect the blood vessels and thus block the supply of nutrients to cancer cells and kill the cancer cells.Methods Calotropis gigantea leaves were selected for the study by chick chorioallantoic membrane CAM assay method using egg where the eggs are incubated for 8 days until the formation of blood vessels and on 8th day CAM layer is cut open and the extract will be tested for anti-angiogenic activity which will cause breakage of blood vessels. Successive solvent extraction of leaves was carried out using petroleum ether chloroform methanol and water and their percentage yield was calculated. Phytochemical screening for all the extract was carried out.Result All extracts were subjected for anti-angiogenic activity where the chloroform extract showed the maximum activity.Conclusion Calotropis gigantea leaves contained anti- angiogenic activity
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