Abstract
Curine is a bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum (Menispermaceae). Recent findings have shed light on the actions of curine in different models of allergy and inflammation. Here we review the properties and mechanisms of action of curine focusing on its anti-allergic effects. Curine pre-treatment significantly inhibited the scratching behavior, paw edema and systemic anaphylaxis induced by either ovalbumin (OVA) in sensitized animals or compound 48/80, through mechanisms of mast cell stabilization and inhibition of mast cell activation to generate lipid mediators. In addition, oral administration of curine significantly inhibited eosinophil recruitment and activation, as well as, OVA-induced airway hyper-responsiveness in a mouse model of asthma, through inhibition of the production of IL-13 and eotaxin, and of Ca2+ influx. In conclusion, curine exhibit anti-allergic effects in models of lung, skin and systemic allergy in the absence of significant toxicity, and as such has the potential for anti-allergic drug development.
Highlights
An Overview of AllergyAllergic disorders result from an exacerbated immune response to substances which are innocuous for most people
Curine is a bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum (Menispermaceae)
The immunomodulatory effects produced by the plant extract, as well as warifteine include inhibition the proliferation of splenocytes and increased IL-10 production [7], inhibition of production of ovalbumin (OVA) -specific IgE [8] and inhibition of anaphylactic shock induced by OVA [9]; inhibition of recruitment and activation of eosinophils in vivo, associated with reduced production of eotaxin and cysteinyl leukotrienes (CysLTs) [10]; inhibition of mast cell activation in vitro [11], in addition to modulation of airway hyperreactivity (AHR) and of airway remodeling in experimental asthma model [12]
Summary
Allergic disorders result from an exacerbated immune response to substances which are innocuous for most people. The allergic reactions to specific antigens require a prior step known as sensitization, which consists in a series of events that result in the production of IgE and their binding to high-affinity Fcε receptors (FcεRI) on mast cells or basophils in the tissue [24]. In this process, dendritic cells (DCs) recognize, capture and are activated by the allergen [25,26,27]. Despite the variety of anti-allergic therapies currently available, the demand for new treatments for the development of safe and effective drugs for the treatment of asthma and other allergic diseases remains a major research field
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
