Anti-allergic activity of standardized extract of Albizia lebbeck with reference to catechin as a phytomarker

Abstract

Background and aim: The major groups of phytonutrients found in plants include polyphenols, flavonoids, terpenes, amines, etc., all of which are observed to have potential anti-allergic activity. In this study, we evaluated the anti-allergic activity of the standardized extract of Albizia lebbeck with respect to the catechin, a polyphenolic phytomarker.Material and methods: The percentage of catechin in the ethanolic extract was found to be 14.72 mg/g. We administered Albizia lebbeck (50–300 mg/kg) and 50 mg/kg of catechin to mice to evaluate the mast cell stabilization and estimation of histamine elevation in the plasma.Results and conclusion: Results support the conclusion that Albizia lebbeck at different concentrations has got potent mast cell stabilizing property and the IC50 value of Albizia lebbeck was found to be 85 μg/ml. This inhibitory potential of catechin from Albizia lebbeck is perhaps due to modulation of two important effector’s functions, histamine release and cytokine expression of antigen -IgE activated mast cells.