Abstract
Purpose: This research was carried out to investigate the moisturizing effects of Ganoderol A on normal human epidermal keratinocytes (NHEKs). Methods: The moisturizing effects of Ganoderol A on NHEKs were measured by quantitative realtime RT-PCR to verify the gene expressions related to skin hydration, hyaluronic acid (HA)-enzyme-linked immunosorbent assay (ELISA) to detect HA production, and cell viability assays. Results: Ganoderol A increased the mRNA levels of the aquaporin 3 (AQP3 ) and hyaluronan synthase 2 (HAS2 ) genes and the production of HA in NHEKs. On the other hand, Ganoderol A decreased the mRNA levels of the keratin 1 (KRT1 ) and keratin 10 (KRT10 ) genes, which are known as differentiated keratinocyte markers, in NHEKs. Conclusion: This research showed the moisturizing effects of Ganoderol A. The results indicate that Ganoderol A can be a potent functional ingredient for skin hydration and anti-aging products. Further study is warranted regarding the use of Ganoderol A to develop not only cosmetics but also food and medicine.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
