Abstract
Anti-aging effect of Radix polygoni multiflori preparata in aging mice model was examined by bioassay method and explore new model of quality control of Traditional Chinese Medicine. Model of aging mice induced by D-galactose were used. The activity of senescence associated molecular markers such as superoxide dismutase, malondialdehyde and glutathione peroxidase in serum or homogenate were determined to evaluate the anti-aging activity. The results showed that the polysaccharide content in the 0.4, 0.8 g/mL decoction were 80.1, 160.2 mg/mL respectively. The HPLC results showed that stibene glucoside content in the 0.4 and 0.8 g/mL decoction were 404 and 808 mg/mL respectively. Experimental results showed that 10 week-old mice were the most sensitive to SOD activity in homogenate. In conclusion, Radix polygoni multiflori preparata has anti-aging effect probably by removing ROS.
Highlights
According to the aging theory, the production of reaction oxygen species (ROS) or free radicals could injure cells and tissues paralleled by malfunction of many systems, and eventually lead to aging and cell death (Goldberg et al, 2014).Glycation is a non-enzymatically driven reaction between free amine groups, and the ( Maillard ) reaction eventually leads to the formation of advanced glycation end products (AGEs)
Glycation is thought to play an important role in aging and the AGEs exacerbate and accelerate the aging process, because AGEs and their precursors usually contain reactive carbony groups generated by ROS (Tian et al, 2005; Semba et al, 2005; Chen et al, 2012; Stadtman, 1992)
Radix polygoni multiflori preparata is used to replenish the liver and kidney with vital essence and blood, blacken the hair and strengthen the tendons and bones according to traditional Chinese medicine theory
Summary
According to the aging theory, the production of reaction oxygen species (ROS) or free radicals could injure cells and tissues paralleled by malfunction of many systems, and eventually lead to aging and cell death (Goldberg et al, 2014). It becomes Radix polygoni multiflori preparata after being processed with black soybean juice according to the processing methods recorded in. Radix polygoni multiflori preparata is used to replenish the liver and kidney with vital essence and blood, blacken the hair and strengthen the tendons and bones according to traditional Chinese medicine theory. The present study demonstrated that Raix polygoni multiflori preparata possessed anti-aging effect by removing free radical, repairing injured gene, enhancing the body’s immune function, delaying cell aging or other mechanism (Tan, 2004). No recent literature demonstrated the anti-aging effect of Radix polygoni multiflori preparata by bioassay method
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