Abstract
Quercus mongolica (QM)—a member of the Fagaceae family—has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5α-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA). QML and PD was also showed the decreases of IL-6 and IL-8 compared with the PC, EGCG and exhibited potent 5α-reductase type 1 inhibitory activities compared with the PC, dutasteride.
Highlights
Keratinocytes play a role in skin barrier function
The structure of the PD was identified by analysis of 1 H-NMR
The leaves of Quercus mongolica (QM) were collected from Yeoju Eco Park, Yeoju, Republic of Korea (GPS coordinates: 37.346648, 127.494519) in July 2018
Summary
Keratinocytes play a role in skin barrier function. When these keratinocytes are exposed to external stimuli like air pollution, stress and ultraviolet radiations it can induce mediator of inflammation, nitric oxide (NO) and inflammatory response such as inflammatory cytokines. NO and the inflammatory cytokines may cause acne vulgaris (AV) [1,2,3,4]. NO is a free radical that damages to cell, tissue and DNA. NO can form peroxynitrite that is a potent cytotoxic agent damage to molecules in cells, including DNA. These damages evoke many chronic inflammatory diseases such as psoriasis and pathogenesis of AV. It was reported that nitrate and nitrite levels which are an index of NO production were high in acne patients [5,6]
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