Abstract
1. 1. Acid secretion for each dog has reached a near maximum (100%) at the 6th samples, 90 min after the intravenous infusion of histamine (10 μghr −1, or approximately equal to 0.3 mghr −1). 2. 2. 0.5 mgkg −1 Cimetidine had produced a mean inhibition of 47% on the stomach. 3. 3. 0.1 mgkg −1 Ranitidine (D 14,951) could only inhibit a maximum of 28%, and the secretion had return to normal in just 30 min. 4. 4. 0.025 mgkg −1 Tiotidine (D 15,104) had inhibited 53% acid secretion within 15 min of exposure. Recovery was quite similar to that of Cimetidine, at 150 min. 5. 5. At a dosage one fifth of Cimetidine (0.1 mgkg −1) D 15,144 had depressed 35% of acid secretion at the first 15 min. The inhibition is gradually increased to about 43% (at 30 min), and was maintained for the next 105 min.
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