Abstract
<p>The hypoglycemic activity of <em>Guiera senegalensis</em> used in Burkinabe folk medicine has been already reported. The aim of this study was to investigate the in <em>vitro</em> antidiabetic activity from galls of <em>G.senegalensis</em>. The extracts and methanol fractions from galls of <em>G. senegalensis</em> showed strong α-glucosidase inhibitory activity compared with acarbose. The ethyl acetate fraction from methanol extract (EA/ME) showed potent antiglycation activity in an <em>in vitro</em> assay system. The galls did not show inhibition activity against α-chymotrypsin. The α-glucosidase inhibitory activity along with its antiglycation activity may open a new perspective for the use of <em>G. senegalensis</em> for the diabetic subject. The data suggests that consumption of <em>G senegalensis</em> galls as an infusion or in food and pharmaceutical preparations may be useful for the management of diabetes and its complications.</p>
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