Abstract
GHIS (Laron Syndrome) is characterised by normal or elevated GH secretion, impaired IGF-I production, characteristic facial phenotype and extreme growth failure. 3 patients with GHIS [basal GH(mU/L) 102, 34.5, 99.5 respectively; IGF-I (μg/L) generation test (GH 0.1U/kg/day for 4 days s.c.) 24 (before) −27 (after), 26 - 26, 24 - 20] received therapy with recombinant IGF-I (IGEF, Kabi Pharmacia) at 120 μg/kg b.d. s.c. Anthropometry gave the following results:
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