Abstract
Objective: To analyze the anthropometric parameters used as alternatives to identify visceral fat and cardiovascular risk in patients with hepatitis C. Methodology: Study carried out between June to November of 2017, with hepatitis C patients. Social data, lifestyle and biochemical parameters were collected. Anthropometric assessment was carried out, being measured height, weight, waist circumference and hip circumference were measured. Then, body mass index, waist and height ratio, waist-to-hip ratio, visceral adiposity index and Framinghan risk score were calculated. For statistical analysis, chi-square test was applied, and simple and multiple logistic regressions have been performed to explore the correlation between anthropometric parameters and Framingham risk score, adopting a 5% significance level. Statistical Package for Social Science software was used. Results: 55 patients evaluated. It was observed that 56.36% presented cardiovascular risk according to waist circumference and waist-to-hip ratio, 78.18% according to the waist and height ratio, and 74.55% according to the visceral adiposity index. In the relation between Framingham risk score and anthropometric parameters it was observed that waist-to-hip ratio was considered a significant independent predictor (OR=14.7000; CI95% = 3.5360 – 61.1180). Conclusion: For the identification of visceral fat, it is suggested to use the waist-to-hip ratio because it indicated a probability for the development of cardiovascular events in individuals with hepatitis C.
Highlights
The hepatitis C virus (HCV) infection allows metabolic alterations that may contribute to the development of metabolic syndrome, and insulin resistance (IR), type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) (Negro 2014)
Schmidt and Benet (2018) evidence that the high percentage of body fat observed in chronic hepatitis C patients is considered as an important risk factor to the appearance of CVD and other associated complications
*Logistic regressions; BMI, body mass index; CI, confidence interval; CVD, cardiovascular diseases; OR, odds ratio; VAI, visceral adiposity index; WC, waist circumference; WHR, waist-to-hip ratio; WHtR, waist and height ratio; Source: Authors. In this present study was possible analyzed the anthropometric parameters of risk identification to cardiovascular diseases in patients diagnosed with hepatitis C
Summary
The hepatitis C virus (HCV) infection allows metabolic alterations that may contribute to the development of metabolic syndrome, and insulin resistance (IR), type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) (Negro 2014). It is believed that the infection may allow chronic inflammation and can be responsible for possible modifications of the vascular endothelium (Badawi et al, 2018). It is suggest that HCV can promote atherogenesis and its complications through different biological mechanisms, from which involve the virus’ colonization and replication inside the arterial walls, hepatic steatosis and fibrosis, inflammatory cytokines’ increased and unbalanced secretions, oxidative stress, cellular and humoral disorders, hyperhomocysteinemia, IR and T2DM (Domont & Cacoub, 2016). Due to metabolic alterations and extrahepatic manifestations observed in patients, it is common to observe overweight in these individuals (Menta et al, 2015). Alves, Schmidt and Benet (2018) evidence that the high percentage of body fat observed in chronic hepatitis C patients is considered as an important risk factor to the appearance of CVD and other associated complications
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