Abstract
Anthrax Toxins and their receptors
Highlights
Under unfavorable growth conditions, B.anthracis undertake the developmental process of sporulation
The anthrax toxin is composed of two binary combinations of three soluble proteins: 83 kDa protective antigen (PA83), 90 kDa lethal factor (LF), and 89 kDa edema factor (EF)
A tripartite AB-type anthrax toxin is comprised of two catalytic A moieties: lethal factor (LF) and edema factor (EF) and a single receptor-binding B moiety, designated as protective antigen (PA)
Summary
B.anthracis undertake the developmental process of sporulation. The anthrax toxin is composed of two binary combinations of three soluble proteins: 83 kDa protective antigen (PA83), 90 kDa lethal factor (LF), and 89 kDa edema factor (EF). It binds to one of two known anthrax toxin receptors, tumor endothelial marker-8 (TEM-8) or capillary morphogenesis protein-2 (CMG-2) [3].
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