Abstract
The development of chemical agents that cleave the backbone of DNA has been spurred by a desire to isolate functional DNA sequences1 and to develop agents that image (footprint) molecules bound to DNA.2 Synthetic nucleases are structurally diverse compounds that operate by three general mechanisms: hydrolysis of the sugar phosphate bond,3 chemical modification of a DNA base,1a,b,4 or hydrogen abstraction from a deoxyribose unit.5 We recently described a set of anthraquinone derivatives that act as photonucleases.6
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