Abstract

Purple corn has been utilized as a daily food and exerts disease‐preventive activities. This study elucidated that anthocyanins‐rich purple corn extract (PCE) prevented glomeruloscleosis. Human endothelial cells and THP‐1 monocytes were treated in conditioned media of mesangial cells experienced to 33 mM high glucose (HG). PCE decreased expression of VCAM‐1 and E‐selectin and monocyte integrins of β1 and β2 induced in HG‐conditioned media. PCE demoted HG‐induced mesangial secretion of interleukin (IL)‐8, demonstrating its inhibition of monocyte adhesion. PCE attenuated monocyte adhesion and infiltration through blocking pro‐inflammatory signaling of Tyk2 and STAT1/STAT3 activated by IL‐8. db/db mice were treated with 10 mg/kg PCE for 8 weeks. PCE alleviated mesangial expansion of diabetic kidney. It was revealed that in kidney glomerulus PCE attenuated induction of the leukocyte adhesion key factors of intracellular cell adhesion molecule‐1 and CD11b. In addition, PCE diminished the levels of the macrophage makers of CD68 and F4/80 in the mesangial interstitum. These results demonstrate that PCE antagonized monocyte infiltration and accumulation possibly through mesangial inflammation of IL‐8 signaling due to chronic hyperglycemia. Therefore, PCE may be potent therapeutic agent for the prevention and treatment of diabetes‐associated glomerulosclerosis accompanying kidney dysfunction.

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