Abstract
Hyperglycemia and insulin resistance are caused by high fat, fructose, or fat and fructose diet. The aim of this study was to investigate the effect of anthocyanin extract of purple corn (AEPC) on insulin resistance of rats fed high fat and fructose diet (HFFD). Insulin resistance was induced by feeding HFFD for 4 weeks and Wistar male rats were orally supplemented with the following treatments for the next six weeks: pioglitazone 1.35 mg kg-1 body weight (bw) as a positive control group (PC), AEPC 6 mg kg-1 bw (LA), AEPC 12.5 mg kg-1 bw (MA), and AEPC 25 mg kg-1 bw (HA), or no treatment as a negative control group (NC). A normal control group was fed a normal diet (NLC) for along 10 weeks. Insulin resistance was indicated by Homeostasis Model Assessments for Insulin Resistance (HOMA-IR) scores. The results showed that HFFD feeding increased HOMA-IR score and blood glucose levels, and decreased levels of plasma glucagon-like peptide 1 (GLP1) and pancreatic glucagon-like peptide 1 receptor (GLP1R). Administration of AEPC reduced HOMA-IR scores and blood glucose levels, increased HOMA-β and HOMA-IS scores, plasma GLP1 and pancreatic GLP1R levels, and improved pancreatic morphology. Our finding suggests that AEPC 12.5 mg kg-1 bw gave the best conditions to improve insulin resistance as well as standard drug administration pioglitazone 1.35 mg kg-1 bw via GLP1 and GLP1R mechanism.
Highlights
The global prevalence of diabetes was estimated to be 9% in 2014 [1]
Treatment of anthocyanin extract of purple corn (AEPC) 12.5 mg kg-1 bw produced the same blood glucose levels as standard drug administration. It meant that high blood glucose level caused by high fat and fructose diet (HFFD) could be normalized by AEPC
This study has shown that AEPC administration was able to suppress blood glucose and serum insulin level compared to high fat and fructose diet group
Summary
The global prevalence of diabetes was estimated to be 9% in 2014 [1]. One of the most responsible cause of diabetes is insulin resistance [3]. High-fat diets cause obesity-induced metabolic syndrome [4], oxidative stress [5,6,7], and trigger insulin resistance [8,9,10]. Overconsumption of fructose plays a role in insulin resistance [11,12], obesity [13], and oxidative stress [14,15]. Treatment with antioxidants can prevent hyperglycemia and insulin resistance caused by high-fat and high-fructose diets (HFFD). One type of antioxidant is anthocyanin which is a group of flavonoid compounds that give the colors orange, red, purple, and bright blue, that is found naturally in fruits and vegetables. In Indonesia, purple corn is being cultivated and one of its kind is dark purple corn from Malang, East Java, Indonesia
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
