Anthelmintic Efficacy of Butea Frondosa and Albendazole in Gastrointestinal Nematode Infected Goats of District Indore-madhya Pradesh, India

Abstract

A wide variety of secondary metabolites with intriguing biological functions are produced by plants. The active component of Butea frondosa, palasonin, inhibits the uptake of glucose and depletes the content of glycogen; hence, the mechanism of action of this anthelminthic agent may involve the suppression of energy metabolism. These medications frequently disrupt key parasitic targets, including membrane integrity, microtubules, DNA (intercalation and alkylation), and neural signal transduction. The goal of this study was to determine how well methanolic extracts from Butea frondosa seeds and albendazole worked as anthelmintics against gastrointestinal nematodes. The egg hatch assay (EHA) was used to conduct an in vitro study on several gastrointestinal nematode stages. Using the methods of egg per gram of feces and faecal egg count reduction (FECR) in vivo. Methanolic treatment was given to goats. The extract of Butea frondosa @ 150 mg/kg b.w. on day 0, 3 and 7. Eggs per gram of faeces were recorded as 883.30 ± 94.60, 783.30 ± 70.30, 333.30 ± 98.90, 466.70 ± 66.70 and 616.70 ± 87.20 on day 0, 7, 14, 21 and 28, respectively. The findings of the current study indicated that, the highest efficacy (62.26%) was recorded on day 14, whereas reduced efficacy of 47.10 and 30.18% was recorded on day 21 and 24, respectively.