ANTHELMINTIC EFFECT OF HERBAL COMPOUNDS (BIO-DEWORMER) AGAINST GASTROINTESTINAL PARASITES IN CAMELS

Abstract

Parasitic infections particularly gastrointestinal helminths are the leading cause of production losses in all dairy animals and in camels as well. Synthetic anthelmintics have been used for many years for the control of helminths. However, helminths have developed resistance against most of these synthetic anthelmintic agents including Levamisole, Oxfendazole, Albendazole, Piprazine, and Triclabendazole. Ancient herbs still have excellent therapeutic effects. While facing emerging synthetic anthelminthic resistance, there is a need to focus on plant-based alternative medicines. Phytochemical findings revealed the presence of various biologically active compounds in plants or their extracts that may have anthelmintic effects. This research aimed to study the effect of herbal combinations on 20 mature camels in District Layyah. The 20 camels were split into four groups: C1, C2, C3, and C4, each group contained five camels. The research trial was continued for four weeks. The treatment was given in different concentrations from week 1 to week 4 (Group C1 350 mg/kg, Group C2 400 mg/kg, Group C3 450 mg/kg, and Group C4 as a control one). During research, Blood, serum, and fecal samples were collected to analyze their hematological parameters, serum biochemistry, and fecal egg count. The result revealed that herbal compound gives concentration-related responses, as groups C1, C2 and C3 showed 33.76, 46.60, and 70.23% fecal egg reduction, respectively. In the control group, C4 fecal egg count increased by 0.03%. HPLC analysis of a methanolic extract of an herbal compound showed that the levels of gallic acid, quercitin, and cinnamic acid were 2.37, 3.28, and 0.46 ppm, respectively. Likewise, serum biochemistry of all groups of camels showed no toxicity and adverse effects of herbal compounds. Hematological parameters showed very positive results of herbal compounds on RBCs, WBCs, PCV, and hemoglobin values.