Abstract
Antígeno prostático específico en hombres del municipio de Paipa, Boyacá 2016
Highlights
Prostate-specific antigen (PSA) is a kallikrein-like serine protease produced almost exclusively by the prostate epithelial cells [1], whose main biological function is associated with the mobility of sperm by changing the liquefaction of semen [2]
According to the study findings, the screening of serum PSA levels in men since the first level of medical care is a useful method for detecting prostatic diseases, as it was more likely to observe high values of the biomarker with older age and an indication of prostatic changes in 12% of the subjects, which contributes to the early monitoring of future related pathologies in this population
The authors express that the procedures were based on the ethical norms of the Committee of Responsible Human Research and in accordance with the national and international clinical research regulation, university protocols have been followed for the publication of patient data, and informed consent has been obtained from patients and/or subjects referred to in this article
Summary
Prostate-specific antigen (PSA) is a kallikrein-like serine protease produced almost exclusively by the prostate epithelial cells [1], whose main biological function is associated with the mobility of sperm by changing the liquefaction of semen [2]. With a molecular weight of 30,000 Daltons, it acts as an important organ-specific immunological marker for the early detection and monitoring of patients with prostate cancer (PC) [3]. It is estimated that 15% of male tumors are of prostate origin in developed countries, and 4% of them in developing nations [5]. In Colombia, PC is the leading cause of cancer incidence in the male population. 8,872 new cases of PC are estimated each year, and approximately 2,416 men die each year due to this disease, making it the second cause of mortality and proving that this pathology is increasing [6] [7]
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