Abstract
A patient suffered very severe anterograde and retrograde amnesia following infarction of both medial temporal lobes (hippocampus and adjacent cortex) and the left inferior temporo-occipital area. The temporal stem and the amygdala were intact; these structures do not appear to be critical for new learning in humans. Extension of the left-sided infarct into the inferior temporo-occipital lobe, an area critically involved in visual processing, appears to be responsible for our patient's loss of remote memories.
Highlights
Impaired learning of new information may result from damage to diencephalic structures, the basal forebrain, or medial temporal lobes (Signoret, 1985; Von Cramon et al, 1990; Squire and Zola-Morgan, 1991)
We present a patient with very severe anterograde and retrograde amnesia following bilateral medial temporal and left inferior temporo-occipital infarction
These conclusions agree with animal studies: Zola-Morgan and Squire (1982), using a delayed non-matching-to-sample task in monkeys, demonstrated impaired memory after lesions involving the hippocampus-amygdala, but not the temporal stem
Summary
A patient suffered very severe anterograde and retrograde amnesia following infarction of both medial temporal lobes (hippocampus and adjacent cortex) and the left inferior temporo-occipital area. The temporal stem and the amygdala were intact; these structures do not appear to be critical for new learning in humans. Extension of the left-sided infarct into the inferior temporo-occipital lobe, an area critically involved in visual processing, appears to be responsible for our patient's loss of remote memories
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