Anterior thalamic deep brain stimulation in refractory epilepsy: A randomized, double-blinded study.

Abstract

The safety and effect on seizure frequency of anterior thalamic nucleus deep brain stimulation were studied in this prospective, randomized, double-blinded study. Patients were followed for 12months. The first 6months were blinded with regard to active stimulation or not. After 6months, all patients received active stimulation. Bilateral ANT electrodes were implanted into 18 patients suffering from focal, pharmacoresistant epilepsy. Antiepileptic treatment was kept unchanged from three months prior to operation. The Liverpool seizure severity scale (LSSS) was used to measure the burden of epilepsy. There was no significant difference between the 2 groups at the end of the blinded period at 6months. However, when considering all patients and comparing 6months of stimulation with baseline, there was a significant, 22% reduction in the frequency of all seizures (P=0.009). Four patients had ≥50% reduction in total seizure frequency and 5 patients ≥50% reduction in focal seizures after 6months of stimulation. No increased effect over time was shown. LSSS at 6 months compared to baseline showed no significant difference between the 2 groups, but a small, significant reduction in LSSS was found when all patients had received stimulation for 6 months. Our study supports results from earlier studies concerning DBS as a safe treatment option, with effects even in patients with severe, refractory epilepsy. However, our results are not as encouraging as those reported from many other, mainly unblinded, and open studies.