Abstract
Idiopathic central diabetes insipidus (CDI) is sometimes complicated with growth disturbances.We describe 5 children (4 boys and 1 girl) with idiopathic CDI and growth hormone deficiency (GHD). They were diagnosed as sufferings from CDI by the symptoms of polydipsia and polyuria, and the result of combination tests of water deprivation and Pitressin loading. The provocation tests showed low secretory responses of GH in all cases. One patient presented with panhypopituitarism, and two with hyperprolactinemia. Magnetic resonance imaging (MRI) showed no posterior pituitary high signals in all cases. Other findings were a small anterior lobe in two cases, transection of the pituitary stalk in one case, and a thickened infundibulum in two cases. Four patients who were treated by recombinant GH showed significant and continuous improvement of their height standard deviation (SD) scores.These patients indicate that idiopathic CDI is a heterogeneous disease which is frequently complicated with anterior pituitary dysfunction, especially GHD, and that GH replacement is effective.
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