Abstract
In anterior cruciate ligament (ACL) reconstruction, intrinsic fibroblasts in the tendon grafted across the knee joint are necrotized immediately after transplantation, and cellular repopulation from an extrinsic origin and revascularization sequentially occurs. Recent experimental studies have suggested that VEGF mediates angiogenesis in the intra-articular tendon graft in an early remodeling phase after the ACL reconstruction, and that the cellular proliferation and invasive migration of infiltrative fibroblasts into the grafted tendon are quite inferior to those of normal tendon fibroblasts. Therefore, the slow remodeling process in the tendon graft may be attributed to these inferior potentials of infiltrative fibroblasts.
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