Anterior cingulate and medial prefrontal cortex alcohol cue reactivity varies as a function of drink preference in alcohol use disorder

Abstract

BackgroundFunctional MRI visual cue reactivity studies have not considered that brain responses to various alcohol-containing beverage types may vary as a function of an individual’s drinking patterns and preferences. This study tested whether the brain’s reward system responds differently to visual cues associated with an individuals’ most commonly consumed (“preferred”) alcohol beverage compared with less commonly consumed (“non-preferred”) alcohol beverages in individuals with alcohol use disorder (AUD). MethodsParticipants (N=70) with current AUD completed a standard visual alcohol cue reactivity procedure during fMRI and reported recent alcohol use through the Timeline Followback interview. Alcohol use patterns were used to infer drink preference. Repeated measure ANCOVAs were used to evaluate differences in subjective craving (alcohol urge) and neural reactivity to cues of individual’s “preferred” versus “non-preferred” alcohol beverages. ResultsFifty-four (77%) participants were determined to have a “preferred” alcohol beverage, as defined by their pattern of alcohol use. These participants reported greater subjective alcohol urge (p=0.02) and activation in the anterior cingulate cortex (ACC) (p=0.005) and medial prefrontal cortex (mPFC) (p=0.001)) in response to visual cues associated with their “preferred” versus “non-preferred” alcohol beverage. Individuals with an alcohol preference did not differ from those with no alcohol preference on subjective or neural responses to their “preferred” and “non-preferred” alcohol cues. DiscussionResults suggest alcohol cue-elicited subjective and neural responses vary as a function of alcohol beverage preference in individuals with AUD and a behaviorally defined alcohol preference. Stronger ACC and mPFC activation may reflect greater subjective value of an individual’s “preferred” alcohol beverage cue.