Anterior Chamber OCT Changes Following Penetrating Keratoplasty

Abstract

Abstract Background penetrating keratoplasty (PKP) is performed for a wide spectrum of corneal disorders. Glaucoma due to pupillary block or synechial angle closure or aqueous misdirection is a major complication after keratoplasty. Peripheral anterior synechia (PAS) is recognized as one of the risk factors for graft rejection and may occasionally cause intraocular pressure (IOP) elevation, it is important to evaluate anterior chamber (AC) angle in eyes after PKP Aim of the Work to document OCT changes in the anterior chamber angle after PKP for different pathologies. Patients and Methods this prospective non-randomized study included 10 eyes of 10 patients undergoing penetrating keratoplasty (PKP) for a variety of indications. The patients age ranged from 20 to 60 years. Results the mean postoperative IOP was higher (15.4 ± 4.03 mmHg) than preoperative IOP (12.5 ± 2.46 mmHg), but this difference was not statistically significant [P value = 0.088]. The postoperative mean Temporal TISA was lower (0.24 ± 0.08 mm2) than preoperative Temporal TISA (0.3 ± 0.1 mm2). This difference was statistically significant [P value = 0.015]. The postoperative mean Nasal TISA was lower (0.26 ± 0.1 mm2) than preoperative Nasal TISA (0.34 ± 0.15 mm2). This difference was statistically significant [P value = 0.010]. The postoperative mean IOP in infectious keratitis was higher (16.14 ± 4.63 mmHg) than postoperative mean IOP in keratoconus (13.67 ± 1.53 mmHg), but this difference was not statistically significant [P value = 0.565]. Conclusion there is an increase in IOP post PKP but the difference was not statistically significant. There is narrowing in angle post PKP. The difference was statistically significant in temporal and nasal angles but not statistically significant in superior and inferior angles. The mean IOP was higher in infectious keratitis than keratoconus but the difference was not statistically significant. There is no correlation between corneal diameter and the changes in IOP and angle measurements.