Abstract
The cells from 62 amniotic fluids have been cultured to the stage at which biochemical studies could have been undertaken. Although all cultures showed initial signs of cellular proliferation in only 90% of these were sufficient cells obtained for biochemical assay. If a time limit of 6 weeks was to be imposed, only 58% of the cultures could have been regarded as successful. The problems involved in culturing amniotic fluid cells for the antenatal diagnosis of inborn errors of metabolism are discussed.
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