Antenatal Bilateral Renal Vein Thrombosis with Combined Protein S and C Deficiency

Ksibi Imen,Achour Radhouane,Bennour Wafa,Ben Jamaa Nadia

doi:10.4172/2167-0897.1000233

Ksibi Imen, Achour Radhouane + Show 2 more

Open Access

https://doi.org/10.4172/2167-0897.1000233

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Journal: Journal of neonatal biology	Publication Date: Jan 1, 2016
Citations: 1	License type: cc-by

Affiliation: Tunis El Manar University

Abstract

In neonates, renal vein thrombosis (RVT) is the second most common thrombosis.We report a case of antenatal bilateral RVT and we review the optimal therapeutic approaches. I, a male newborn was admitted in the Neonatal Intensive Care Unit of the Center for Maternity and Neonatology of Tunis (CMNT) for respiratory distress and gross hematuria. Initial laboratory work demonstrated renal impairment and Doppler renal ultrasound confirmed the diagnosis of bilateral RVT. Thrombophilia evaluation found a combined protein C and S deficiency. Thrombolysis was started with tissue plasminogen factor in association to anticoagulation with unfractionated heparin. Renal vein thrombosis in neonates is a rare condition with a high morbidity rate. Thrombotic conditions may be associated with more severe clinical presentations. Currently, there is a lack of consensus concerning the management of RVT.

Highlights

Neonates have a higher incidence of thrombosis when compared to older children [1,2]
We report a case of antenatal bilateral renal vein thrombosis (RVT) and we review the optimal therapeutic approaches
We report the case of a newborn male infant born with antenatal bilateral renal vein thrombosis (RVT) associated to a renal impairment

Summary

Introduction

Neonates have a higher incidence of thrombosis when compared to older children [1,2]. Renal vein thrombosis (RVT) in neonates is the second most common thrombosis It is a rare and severe condition associated to a high morbidity rate. There was no familial history of thromboembolism events He was admitted in the Neonatal Intensive Care Unit (NICU) at birth for respiratory distress related to transient respiratory distress. He was voiding spontaneously with gross hematuria. By the seventh day of life, clinical examination demonstrated poor neurologic function with left paralysis, so urgent cranial ultrasound was done and demonstrated right diffuse periventricular hyperechogenicity. By the third week of treatment, renal ultrasound was normal. He was discharged from the hospital at the age of 30 days.

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